Robin

Rapidly Increasing Serum 25(OH)D Boosts the Immune System against Infections-“Sepsis and COVID-19”  

Dear Vitamin D Researchers, Medical Professionals and/or Advocates:  

Question: Why should doctors or the public notice vitamin D researchers if immunologists are unaware of 25-hydroxyvitamin D’s importance to the immune system?  

I can only do a fraction of what I would like to regarding highlighting the best research and bringing it to the attention of others who need to read it, including every immunologist I know of.   https://vitamindstopscovid.info/00-evi/  

Much of this material is covered by the following article, which I will link to from the above page:  

Rapidly Increasing Serum 25(OH)D Boosts the Immune System against Infections—Sepsis & COVID-19   

Sunil J. Wimalawansa, Nutrients 2022-07-21: full- https://www.mdpi.com/2072-6643/14/14/2997/htm  

[https://www.mdpi.com/2072-6643/14/14/2997]  

I am updating my charts (https://vitamindstopscovid.info/00-evi/#charts) to be compatible with above-revised recommendations for vitamin D3 daily supplemental intake quantities as ratios of body weight.   

I based these charts and the submission on his earlier recommendations to the FLCCC, now cited in some of their protocols:   

COVID-19 Protocols

      (https://covid19criticalcare.com/covid-19-protocols/i-prevent-covid-protection-protocol/) Also updated now.  

Dr Wimalawansa’s recent article highlights the need for at least 50 ng/mL circulating 25-hydroxyvitamin D for immune system health, with higher levels for those suffering from inflammatory auto-immune disorders.   

It makes a crucial distinction between the hormonal function of circulating 1,25-dihydroxyvitamin D, for regulating calcium-phosphate-bone metabolism and the immune system’s need for 50 ng/mL circulating 25(OH)D.  The latter is not acting as a hormone. Immune cells are not affected by the very low, and generally stable, level of circulating 1-,25-dihydroxyvitamin D.

Intracrine signaling is within individual cells. Paracrine signaling is to nearby cells, typically of a different type.  These systems are crucial to the ability of many types of immune cell to respond to their circumstances.  The details have only been elucidated in detail for a subset of immune cell types by Martin Hewison et al. (macrophages and dendritic cells) and Chauss et al. (Th1 lymphocytes remaining stuck in their pro-inflammatory startup program due to lack of 259OH)D).   

However, since most or all immune cells are known to alter their gene expression according to VDR activation, it is reasonable to assume that most such cell types are involved in vitamin D based intracrine and/or paracrine signaling. 
For all non-immune-system, cell types which are also known to alter gene expression according to VDR activation – other than those involved in calcium-phosphate-bone metabolism – these also depend on vitamin D based intracrine and/or paracrine signaling to respond to each cell’s changing circumstances.  

There is a critical need for vitamin D researchers to explain this properly, especially to immunologists, since immunologists seem to have no knowledge of or interest in vitamin D.   I have two recent, highly regarded immunology texts here – 1500s full of all sorts or details and intriguing research: Janeways 9th and Abbas 10th.  Neither mention vitamin D in their indexes.  

At present, the best explanations of vitamin D-based intracrine and paracrine signaling systems, and of why “vitamin D” is not a hormone I know of are:  

https://vitamindstopscovid.info/02-intracrine/  (cites Reinhold Vieth 2004 Why Vitamin D” is not a hormone, and not a synonym for  1,25-dihydroxy-vitamin D, its analogs or deltanoids.)  

https://vitamindstopscovid.info/00-evi/#02-compounds

While Dr Wimalawansa’s article also draws the crucial distinction between these signaling systems and hormonal signaling. He highlighted the time it takes (months) to attain proper 25(OH)D with suitable quantities of supplemental vitamin D3 and how inadequate this is for clinical emergencies.  He discusses bolus vitamin D3 (~~ 4 days to raise 25(OH)D levels over 50 ng/mL) and, most importantly, the use of 0.014 mg per kg bodyweight (1mg for 55 to 85 kg) calcifediol to raise these levels safely over 50 ng/mL in 4 hours or so.  

https://www.linkedin.com/posts/sunilwimalawansa_ivermectin-for-covid-19-real-time-analysis-activity-6829805643533287424-8Wuv

Simplified Protocol for Using Vitamin D, Calcifediol, & Ivermectin:    

https://www.linkedin.com/posts/sunilwimalawansa_simplified-protocol-for-using-vitamin-d-activity-6834224355317207040-yIEv

100 or so such tablets can be made into an easy-to-drink suspension by adding a small amount of xanthan gum and water. See the end of:  https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin

 

COVID-19 is not the most dramatic example of harm and death due to inadequate vitamin D3 intake.  Sepsis is arguably worse since it kills 11 million people a year and would only rarely occur or kill people if everyone had 50 ng/mL 25(OH)D: Global Burden of Disease project: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/   

Boosting innate immunity with vitamin D could help reduce complications and deaths from COVID-19: recent advances (video).   

https://www.linkedin.com/posts/sunilwimalawansa_reduction-of-complications-of-covid-19-with-activity-6759684685204455424-w-Bw

For children:  

Multisystem Inflammatory Syndrome (MIS) and Kawasaki-like syndrome & COVID-19:
https://www.linkedin.com/posts/sunilwimalawansa_multisystem-inflammatory-syndrome-mis-activity-6815294839769436160-99qJ     

Finally, years of evidence show that flu vaccines do not reduce hospitalisation or death due to influenza or influenza-like illnesses, at least directly in those too are vaccinated.  See Anderson et al. 2020 and other research cited at: https://nutritionmatters.substack.com/p/influenza-vaccines-do-not-reduce .  

  Best regards  

    Robin (rw@firstpr.com.au)